GLP-1 Medication Level Chart — Why Hunger Returns Before Your Next Shot

"Why am I hungry again before my next shot?" is the question that panics new GLP-1 users on day six — when the scale was moving and food noise was gone, then suddenly pizza sounds interesting again.

GLP-1 medications have a weekly rhythm

Weekly injections (Mounjaro, Zepbound, Wegovy, Ozempic) do not deliver a flat level of drug all week. After each dose:

1. Days 1–2 — levels rise; appetite suppression often feels strongest
2. Days 3–5 — mid-cycle plateau for many people
3. Days 6–7 — levels taper; hunger may return before the next injection

This is pharmacology, not failure.

Half-life in plain English

| Medication type | Examples | Approx. half-life | | --- | --- | --- | | Semaglutide | Wegovy, Ozempic | ~7 days (DailyMed) | | Tirzepatide | Mounjaro, Zepbound | ~5 days (DailyMed) |

Half-life means how long it takes for half the drug to clear, per the official prescribing labels. With weekly dosing, levels build up over the first few weeks, then settle into a repeating weekly wave.

See your dose cycle visually

The free GLP-1 medication level chart shows:

• Estimated relative levels over 4–16 weeks
• Weekly injection markers on the timeline
• Semaglutide vs tirzepatide comparison
• Where you are in the current 7-day cycle

Pair the chart with real logging — appetite, side effects, weight — in GLPPal to see your pattern vs the general model.

Open the medication level chart → · Appetite tracker → · Download on the App Store →

Track your GLP-1 journey with GLPPal

GLPPal helps you log injections, appetite, weight and side effects in one calm app — built for Mounjaro, Zepbound, Wegovy and other GLP-1 users.

Sources

• Wegovy prescribing information — DailyMed (NIH/FDA)
• Zepbound prescribing information — DailyMed (NIH/FDA)
• Mounjaro prescribing information — DailyMed (NIH/FDA)

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GLPPal is designed for tracking and educational purposes only and is not medical advice. Always follow your healthcare provider's guidance.